MicroRNAs and rs1803274 SNP-based BuChe downregulation are associated with metabolic syndrome through ghrelin hydrolysis and expression quantitative trait loci regulation in PD patients
The SNV variant rs1803274 was associated with both MetS and PD and downregulated the expression of BuChe, which is involved in ghrelin hydrolysis. This variant was associated with several MetS-related eQTLs proteins or their components.
Authors
- Francisco Capani (ORCID: https://orcid.org/0000-0003-0342-0628)
- Lucas Udovin
- Sofía Bordet
- Santiago Perez‐Lloret (ORCID: https://orcid.org/0000-0001-9069-6512)
- Matilde Otero‐Losada (ORCID: https://orcid.org/0000-0001-6650-1033)
- Guenson Chevalier (ORCID: https://orcid.org/0000-0001-8017-9458)
Institutions
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- Universidad de Buenos Aires (AR)
- Universidad Abierta Interamericana (AR)
- Pontificia Universidad Católica Argentina (AR)
- Universidad Autónoma de Chile (CL)
Publication Details
- Journal
- Frontiers in Molecular Neuroscience
- Published
- 2025-11-10
- DOI
- https://doi.org/10.3389/fnmol.2025.1635201
- Primary Topic
- Regulation of Appetite and Obesity
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Bristol-Myers Squibb
- Eli Lilly and Company
- Pfizer
- GlaxoSmithKline
- Sanofi
- Biogen
- Teva Pharmaceutical Industries
- Celgene
- Neurocrine Biosciences
- Verily Life Sciences
- Voyager Therapeutics
- Servier
- Universidad Abierta Interamericana
- H. Lundbeck A/S
- Genentech
- Allergan
- Sanofi Genzyme
- Avid Radiopharmaceuticals