Efficacy and safety of epsilon-aminohexanoic acid and tranexamic acid during posterior interbody fusion surgery

There was no significant difference in total blood loss, total red blood cell loss, transfusion volume/rate, postoperative hospitalization time, hospitalization costs, and surgical complications between the intravenous EACA and TXA groups during PLIF surgery. The two groups had similar hemostatic effects and safety outcomes. Therefore, when selecting antifibrinolytic drugs during PLIF surgery, EACA can be considered an alternative to TXA. However, large-scale, multicenter randomized controlled studies are still required to gauge its later-stage efficacy.