Impact of iron chelation therapy on mitochondrial function, vascular integrity and inflammation in transfusion-dependent myelodysplastic syndromes
Iron chelation may modulate disease-relevant redox, endothelial, and cytokine pathways in transfusion-dependent MDS, generating mechanistic hypotheses for prospective clinical validation. These findings support the concept that NTBI reduction mitigates pathogenic processes relevant to disease progression, warranting confirmation in prospective studies integrating clinical endpoints.
Authors
- Rodolfo Matías Ortiz Flores (ORCID: https://orcid.org/0000-0003-4509-0161)
- Alejandro Escamilla (ORCID: https://orcid.org/0000-0001-9135-5330)
- Juan Antonio López-Villodres (ORCID: https://orcid.org/0000-0002-2451-7245)
- Silvia García-Segovia
- Gloria Moreno‐Carrasco
- Regina García‐Delgado
- Julio Torres-González
- Manuel Carrasco-Gomariz
- Gonzalo Gallego-Fuillerat
Institutions
- Andalusian Centre for Nanomedicine and Biotechnology (ES)
- Hospital Clínico Universitario Virgen de la Victoria (ES)
- Instituto de Investigación Biomédica de Málaga (ES)
- Universidad de Málaga (ES)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-11-10
- DOI
- https://doi.org/10.3389/fimmu.2025.1683941
- Citations
- 1
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 1.77
Funders
- Victoria University