Case Report: Possible association between dermatomyositis and Trastuzumab Deruxtecan therapy of triple-negative breast cancer patient
reported here findings suggest that T-DXd may trigger multi-system involvement through immune-mediated mechanisms, resulting in drug-induced dermatomyositis and interstitial pneumonia. Our findings highlight the need for heightened vigilance regarding such immune-related adverse events during T-DXd therapy, where early recognition and intervention are critically important to avoid irreversible and possibly fatal complications.
Authors
- Jing Cai (ORCID: https://orcid.org/0000-0001-6889-0685)
- Maksim Semenov (ORCID: https://orcid.org/0000-0001-9810-9300)
- Chao Li (ORCID: https://orcid.org/0000-0003-1058-4153)
- Ping Zheng (ORCID: https://orcid.org/0000-0002-2508-762X)
- Huan Han (ORCID: https://orcid.org/0009-0005-0103-758X)
- Yuhong Zhang (ORCID: https://orcid.org/0000-0003-4230-5868)
- Taoyan Lin (ORCID: https://orcid.org/0000-0003-0956-0592)
Institutions
- Sun Yat-sen University (CN)
- Shanxi Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Shaanxi Provincial People's Hospital (CN)
- Sun Yat-sen University Cancer Center (CN)
- Shanxi Provincial People’s Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-11-10
- DOI
- https://doi.org/10.3389/fimmu.2025.1636581
- Citations
- 1
- Primary Topic
- Inflammatory Myopathies and Dermatomyositis
- Type
- article
- Field-Weighted Citation Impact
- 1.35