Mechanism of hepatotoxicity induced by ethanol extract of Emilia sonchifolia (L.) DC revealed by proteomics and metabolomics
In summary, the ethanol extract of <i>E. sonchifolia</i> can induce hepatotoxicity in mice, and its mechanism is associated with cholestasis and oxidative stress mediated by disruptions in drug metabolism, steroid hormone biosynthesis, and primary bile acid biosynthesis.
Authors
- Xin Liu (ORCID: https://orcid.org/0000-0002-6542-3181)
- Ping Zheng (ORCID: https://orcid.org/0000-0002-2508-762X)
- Zhongchen Song (ORCID: https://orcid.org/0000-0002-9249-7645)
- Ting Tang (ORCID: https://orcid.org/0009-0005-9078-2417)
- Quanfang Luo
- Gongzhen Chen
Institutions
- Guiyang College of Traditional Chinese Medicine (CN)
- Affiliated Hospital of Guizhou Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-11-10
- DOI
- https://doi.org/10.3389/fphar.2025.1669607
- Primary Topic
- Drug-Induced Hepatotoxicity and Protection
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Department of Education of Guizhou Province