The accuracy of heparin-binding protein and interleukin-6 in predicting prognosis of severe pneumonia with sepsis patients
Serum HBP and IL-6 have comparable predictive efficacy to SOFA score and are numerically superior to PCT, CRP, and Lac. IL-6 also aids early identification of bloodstream infections. However, their cut-offs are from a single-center cohort and require external validation; combined use with SOFA score is recommended clinically.
Authors
- Xiaomeng Xue (ORCID: https://orcid.org/0009-0007-1233-0938)
- Chunli Zhang (ORCID: https://orcid.org/0000-0003-0330-9567)
- Yu Meng (ORCID: https://orcid.org/0000-0002-4010-5603)
- Zhiyong Wei (ORCID: https://orcid.org/0000-0002-8617-847X)
- Maimaitijiang Yusupu
- Xiaoye Wang (ORCID: https://orcid.org/0000-0003-3540-0277)
- Yan Cui (ORCID: https://orcid.org/0000-0003-1644-8400)
- Keliang Xie (ORCID: https://orcid.org/0000-0001-6362-6084)
Institutions
- Tianjin Medical University General Hospital (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-11-10
- DOI
- https://doi.org/10.3389/fcimb.2025.1554214
- Primary Topic
- Sepsis Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00