Tibetan medicine Pa Zhu Wan ameliorates carbon tetrachloride-induced liver fibrosis in rats by regulating the TGF-β-Smad2/3 and IL-6/JAK2/STAT3 signaling pathways
PZW alleviated hepatic fibrosis <i>in vivo</i>, primarily by inhibiting collagen accumulation through navigating IL-6/JAK2/STAT3 and TGF-β/Smad2/3 signaling pathways.
Authors
- Dejun Zhang (ORCID: https://orcid.org/0000-0001-9129-534X)
- Linlin Zhao (ORCID: https://orcid.org/0000-0002-8821-4198)
- Guo Liu (ORCID: https://orcid.org/0000-0001-9068-1601)
- Zhengxing Wang (ORCID: https://orcid.org/0000-0002-5287-3255)
- Jing Ma (ORCID: https://orcid.org/0000-0003-0103-9858)
- Yan Jiang (ORCID: https://orcid.org/0000-0001-9633-8900)
- Yongjing Yang
- Tin Wui Wong
Institutions
- Qinghai University (CN)
- Xintai People's Hospital (CN)
- First People's Hospital of Nanning (CN)
- Universiti Teknologi MARA (MY)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-11-10
- DOI
- https://doi.org/10.3389/fphar.2025.1667685
- Primary Topic
- Liver physiology and pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Qinghai University