Exploring the liver microenvironment following successful therapy for HCV: gene expression profiling and residual T cell infiltration
Even after achieving SVR and normalization of gene expression, the liver retained a heterogeneous T cell infiltrate, suggesting that persistent immune activity could continue to influence the risk of adverse outcomes.
Authors
- Timothy G. Wanninger
- Rongjia Zhang (ORCID: https://orcid.org/0000-0003-1006-6866)
- Kellen Henning
- Esteban Arroyave (ORCID: https://orcid.org/0000-0002-4996-1094)
- Daniel Millián (ORCID: https://orcid.org/0000-0002-9661-7165)
- Santhoshi Krishnan (ORCID: https://orcid.org/0000-0001-5114-9778)
- H. C. Spratt
- Monique R. Ferguson (ORCID: https://orcid.org/0000-0003-1094-8439)
- Vincent Chen (ORCID: https://orcid.org/0000-0002-0157-6066)
- Daniel Bao (ORCID: https://orcid.org/0000-0002-3913-0609)
- Ómar A. Saldarriaga (ORCID: https://orcid.org/0000-0001-7822-108X)
- Heather L. Stevenson (ORCID: https://orcid.org/0000-0002-0645-7621)
- Arvind Rao
Institutions
- University of Michigan (US)
- John Sealy Hospital (US)
- Michigan Medicine (US)
- The University of Texas Medical Branch at Galveston (US)
- Rice University (US)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-11-10
- DOI
- https://doi.org/10.3389/fcimb.2025.1662184
- Primary Topic
- Hepatitis C virus research
- Type
- article
- Field-Weighted Citation Impact
- 0.00