Reduced levels of nitrated α-synuclein in the protective effect of harpagoside on rotenone-induced cellular models of Parkinson’s disease
Detailed pathway analysis indicated that harpagoside's protective actions involved regulation of the nuclear factor-κB (NF-κB)/NOS/NO/α-synuclein nitration signaling cascade.
Authors
- Juan Lang
- Zhongkui Xiong (ORCID: https://orcid.org/0000-0001-7119-965X)
Institutions
- Shaoxing University (CN)
- Shaoxing Second Hospital (CN)
- Shaoxing People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2025-11-10
- DOI
- https://doi.org/10.3389/fcell.2025.1624315
- Primary Topic
- Natural Compound Pharmacology Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Zhejiang Province