Estimating the smallest worthwhile difference of recommended psychotherapies for depression: observational study
Current empirically supported psychotherapy response rates of 15% were sufficient for one in three people to initiate psychotherapy given the burdens, but two in three expected greater treatment benefits or fewer burdens. The SWD for psychotherapy was not materially different from the estimated SWD for antidepressants. Individual patient value judgements and preferences merit greater attention. These findings should be replicated with diverse samples from different geographical locations.
Authors
- Stefan Leucht (ORCID: https://orcid.org/0000-0002-4934-4352)
- Roger Ede (ORCID: https://orcid.org/0009-0007-9712-2539)
- Yan Luo (ORCID: https://orcid.org/0000-0002-5271-5126)
- Andrea Cipriani (ORCID: https://orcid.org/0000-0001-5179-8321)
- Aran Tajika (ORCID: https://orcid.org/0000-0003-3926-8867)
- Astrid Chevance (ORCID: https://orcid.org/0000-0002-0852-4322)
- Sarah Markham (ORCID: https://orcid.org/0000-0002-8755-5935)
- Ethan Sahker (ORCID: https://orcid.org/0000-0002-4269-4800)
- Toshi A. Furukawa (ORCID: https://orcid.org/0000-0003-2159-3776)
- Kenji Omae (ORCID: https://orcid.org/0000-0003-0109-7425)
- Manuela L. Ferreira (ORCID: https://orcid.org/0000-0002-3479-0683)
- Georgia Salanti (ORCID: https://orcid.org/0000-0002-3830-8508)
Institutions
- University of Bern (CH)
- Inserm (FR)
- King's College London (GB)
- Université Paris Cité (FR)
- Kyoto University (JP)
- Hotel Dieu Hospital (CA)
- Oxford Health NHS Foundation Trust (GB)
- Warneford Hospital (GB)
- UNSW Sydney (AU)
- University of Oxford (GB)
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
- Université Sorbonne Paris Nord (FR)
- Sorbonne Paris Cité (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- The George Institute for Global Health (AU)
- Health Biomed (China) (CN)
- Hôtel-Dieu de Paris (FR)
- Institute of Social and Preventive Medicine (CH)
- Oxford BioMedica (United Kingdom) (GB)
- Fukushima Medical University Hospital (JP)
- Technical University of Munich (DE)
Publication Details
- Journal
- The British Journal of Psychiatry
- Published
- 2025-11-10
- DOI
- https://doi.org/10.1192/bjp.2025.10453
- Citations
- 3
- Primary Topic
- Treatment of Major Depression
- Type
- article
- Field-Weighted Citation Impact
- 4.18