Exploring the cortisol awakening response in premenstrual dysphoric disorder and in healthy females across the menstrual cycle
Patients with PMDD showed attenuated cortisol peaks in the periovulatory phase compared with healthy controls, who demonstrated plastic changes across the cycle. Results point towards an interplay between the stress and the serotonergic system, as well as to the severity of depressive symptoms during the premenstrual phase.
Authors
- Osama Sabri (ORCID: https://orcid.org/0000-0002-6425-3504)
- K Hoffmann (ORCID: https://orcid.org/0000-0003-4723-9337)
- Arno Villringer (ORCID: https://orcid.org/0000-0003-2604-2404)
- Rachel G. Zsido (ORCID: https://orcid.org/0000-0002-3743-5871)
- Julia Sacher (ORCID: https://orcid.org/0000-0003-0944-0558)
- Veronika Engert (ORCID: https://orcid.org/0000-0001-5317-933X)
- Swen Hesse (ORCID: https://orcid.org/0000-0002-2055-2764)
Institutions
- Leipzig University of Applied Sciences (DE)
- Humboldt-Universität zu Berlin (DE)
- University Hospital Leipzig (DE)
- Max Planck Institute for Human Cognitive and Brain Sciences (DE)
- Jena University Hospital (DE)
- Center for Pain and the Brain (US)
- Friedrich Schiller University Jena (DE)
- Leipzig University (DE)
Publication Details
- Journal
- The British Journal of Psychiatry
- Published
- 2025-11-10
- DOI
- https://doi.org/10.1192/bjp.2025.10432
- Citations
- 1
- Primary Topic
- Menstrual Health and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.88
Funders
- Massachusetts General Hospital
- Deutsche Forschungsgemeinschaft
- Max-Planck-Gesellschaft
- Humboldt-Universität zu Berlin
- Universitätsklinikum Jena
- Max-Planck-Institut für Kognitions- und Neurowissenschaften