Electrosynthesis of β‐Hydroxy Ketones Directly from Ketones with Methanol as a Hydroxymethylating Reagent
An electrochemical cross coupling for ketones and methanol is developed, providing an efficient access to β‐hydroxy ketones. In this protocol, the biofuel methanol is readily used as a hydroxymethylating reagent to couple with ketones with hydrogen as the only by product. This sustainable reaction proceeds smoothly in an aqueous medium, giving diverse β‐hydroxy ketones in 26%–92% yields at room temperature in the absence of exogenous oxidants.
Authors
- Wenjing Xiong (ORCID: https://orcid.org/0000-0003-4701-5835)
- Xiyuan Li (ORCID: https://orcid.org/0000-0003-3192-652X)
- Qiang Wei (ORCID: https://orcid.org/0000-0003-3750-3042)
- Jiasheng Wang (ORCID: https://orcid.org/0000-0001-6519-4318)
- Peng Qian (ORCID: https://orcid.org/0000-0002-1428-7028)
- Tongtong Zhu (ORCID: https://orcid.org/0000-0002-5481-6836)
- Yuting Ren (ORCID: https://orcid.org/0009-0009-1992-9809)
- Jinxiu Liu
- Yanan Li (ORCID: https://orcid.org/0009-0003-2141-1212)
Institutions
- Fuyang Normal University (CN)
- Anhui University of Science and Technology (CN)
Publication Details
- Journal
- Advanced Synthesis & Catalysis
- Published
- 2025-11-10
- DOI
- https://doi.org/10.1002/adsc.70104
- Primary Topic
- Radical Photochemical Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00