A prospective randomized crossover trial investigating melatonin versus sleep deprivation for sleep induction in nap electroencephalography
This randomized crossover trial evaluated the effectiveness and tolerability of melatonin administered before an EEG recording to induce sleep, compared with partial sleep deprivation. The results showed that melatonin helped children achieve sleep and was non-inferior to sleep deprivation. Moreover, melatonin demonstrated a favorable tolerability profile, representing a safe and easier alternative to support sleep during EEG, particularly in children with neurodevelopmental disorders, and could enhance the efficiency and quality of pediatric EEG recordings.
Authors
- Paola Rota (ORCID: https://orcid.org/0000-0001-5795-4989)
- Francesca Ferraro (ORCID: https://orcid.org/0000-0003-0098-9819)
- Costanza Varesio (ORCID: https://orcid.org/0000-0001-5645-021X)
- Carlo Alberto Quaranta (ORCID: https://orcid.org/0000-0002-2076-8848)
- Grazia Papalia
- Michela Palmisani (ORCID: https://orcid.org/0009-0005-7155-9447)
- Guido Fedele
- Ludovica Pasca (ORCID: https://orcid.org/0000-0003-4382-0095)
- Valentina Franco (ORCID: https://orcid.org/0000-0003-4736-4437)
- Massimiliano Celario (ORCID: https://orcid.org/0009-0008-4408-8792)
- Valentina De Giorgis (ORCID: https://orcid.org/0000-0002-5828-7070)
- Cinzia Fattore
Institutions
- University of Milan (IT)
- University of Pavia (IT)
- H.B. Fuller (United States) (US)
- Center for Translational Molecular Medicine (NL)
- Associazione Medici Diabetologi (IT)
Publication Details
- Journal
- Epilepsia Open
- Published
- 2025-11-10
- DOI
- https://doi.org/10.1002/epi4.70169
- Primary Topic
- Sleep and Wakefulness Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00