Wuling San ameliorates cerebral ischemia–reperfusion injury via suppression of the TRPM2/NLRP3 pathway
The present study is the first to prove that WLS improved CIRI and regulated the polarization distribution of AQP4 by targeting the TRPM2/NLRP3 pathway to alleviate brain edema, which is beneficial for neuroprotection and cognitive improvement after CIRI.
Authors
- Yunfei Deng
- Xiehua Xue (ORCID: https://orcid.org/0000-0002-9018-1436)
- Huihong Li (ORCID: https://orcid.org/0009-0006-4572-7176)
- Wei Wei (ORCID: https://orcid.org/0000-0002-3117-9598)
- Yubing Chen (ORCID: https://orcid.org/0009-0008-5407-7683)
- Dengshun Tao
Institutions
- Fujian University of Traditional Chinese Medicine (CN)
- Education Department of Fujian Province (CN)
- Fujian Petrochemical Group (China) (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2025-11-10
- DOI
- https://doi.org/10.1186/s40001-025-03344-2
- Primary Topic
- Ion Channels and Receptors
- Type
- article
- Field-Weighted Citation Impact
- 0.00