Cysteine addiction in drug resistant glioblastoma and therapeutic targeting with designer selenium compounds
Overall, our findings show a unique metabolic environment in TMZ-R models where designer brain penetrant Se-containing compounds target cysteine reactivity within proteins necessary for cancer cell survival and hold therapeutic potential.
Authors
- Deanna Tiek (ORCID: https://orcid.org/0000-0002-2881-7691)
- Marcelo G. Bonini (ORCID: https://orcid.org/0000-0003-1193-1428)
- Junxuan Lü (ORCID: https://orcid.org/0000-0002-2354-7186)
- Arun Kumar Sharma (ORCID: https://orcid.org/0000-0002-2777-8731)
- Qiu He
- Bo Hu (ORCID: https://orcid.org/0000-0002-9882-4053)
- Shi‐Yuan Cheng (ORCID: https://orcid.org/0000-0003-1737-0588)
- Runxin Wu (ORCID: https://orcid.org/0009-0001-4417-2694)
- Jason Miska (ORCID: https://orcid.org/0000-0001-9608-2810)
- Yingyu Mao (ORCID: https://orcid.org/0000-0001-5182-7401)
- Assa Magassa (ORCID: https://orcid.org/0000-0001-6082-0324)
- Xiaoyu Zhang (ORCID: https://orcid.org/0000-0003-1201-4808)
- Amandeep Singh (ORCID: https://orcid.org/0000-0002-0210-5012)
- Maya Walker
- Xiaozhou Yu (ORCID: https://orcid.org/0000-0002-9187-2896)
- Derek Sisbarro
- Xiao Song (ORCID: https://orcid.org/0009-0007-8771-1815)
Institutions
- Northwestern University (US)
- Moffitt Cancer Center (US)
- Cleveland Clinic Lerner College of Medicine (US)
- High Throughput Biology (United States) (US)
- Robert H. Lurie Comprehensive Cancer Center of Northwestern University
- Penn State Milton S. Hershey Medical Center (US)
Publication Details
- Journal
- Neuro-Oncology
- Published
- 2025-11-08
- DOI
- https://doi.org/10.1093/neuonc/noaf265
- Primary Topic
- Selenium in Biological Systems
- Type
- article
- Field-Weighted Citation Impact
- 0.00