Pan-cancer multi-omics analysis reveals IQCE as a malignant cell-restricted oncogenic biomarker driving immunosuppression and chemoresistance in cutaneous melanoma
IQCE emerges as a novel oncogene-associated biomarker with significant diagnostic and prognostic utility, particularly in SKCM. It promotes an immunosuppressive TME and oncogenic signaling while being localized to malignant cells. Although associated with chemoresistance, the vulnerability of IQCE-high tumors to RITA offers a promising therapeutic strategy. IQCE represents a compelling target for precision oncology.
Authors
- Jielong Li
- Ting Chen (ORCID: https://orcid.org/0000-0003-1725-7956)
- Jingya Wang (ORCID: https://orcid.org/0000-0002-4371-4674)
- Qing Luo (ORCID: https://orcid.org/0000-0002-6056-3978)
Institutions
- Xuzhou Medical College (CN)
- Lianyungang Oriental Hospital (CN)
- Second People’s Hospital of Huai’an (CN)
- The First People’s Hospital of Lianyungang (CN)
- Kangda College of Nanjing Medical University
- Nanjing Medical University (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-11-10
- DOI
- https://doi.org/10.1007/s12672-025-03841-0
- Primary Topic
- Cutaneous Melanoma Detection and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00