Implementing oral (event-driven and daily) and long-acting pre-exposure prophylaxis in mobile men in sub-Saharan Africa: a phase 3b, open-label, hybrid type 2 implementation and effectiveness trial (MOBILE MEN)
This study will provide critical data to inform scalable delivery models for both oral and injectable PrEP among mobile men at high risk for HIV acquisition. Findings will also highlight the potential of PrEP choice delivery and its benefits, offering evidence for governments to consider in the rollout of injectable PrEP in public health systems. Trial registration NCT06133686. Registered on 14 November 2023. PACTR202409632006463. Registered on 2 September 2024.
Authors
- Emily L. Webb (ORCID: https://orcid.org/0000-0002-4019-7456)
- Julie Fox (ORCID: https://orcid.org/0000-0002-0583-8019)
- Gesine Meyer‐Rath (ORCID: https://orcid.org/0000-0003-0439-381X)
- Limakatso Lebina (ORCID: https://orcid.org/0000-0001-6825-0573)
- Linda‐Gail Bekker (ORCID: https://orcid.org/0000-0002-0755-4386)
- Eugene Ruzagira (ORCID: https://orcid.org/0000-0002-7291-1693)
- Maryam Shahmanesh (ORCID: https://orcid.org/0000-0001-7129-8535)
- Darshini Govindasamy (ORCID: https://orcid.org/0000-0001-5984-3588)
- Sylvia Kusemererwa (ORCID: https://orcid.org/0000-0002-1390-109X)
- A. Philips
- Geofrey Kimbugwe (ORCID: https://orcid.org/0000-0001-8561-7971)
- Janet Seeley (ORCID: https://orcid.org/0000-0002-0583-5272)
- Bernadette Nayiga
- Loveleen Bansi- Matharu
Institutions
- South African Medical Research Council (ZA)
- Desmond Tutu HIV Foundation (ZA)
- King's College London (GB)
- University of the Witwatersrand (ZA)
- London School of Hygiene & Tropical Medicine (GB)
- Africa Health Research Institute (ZA)
- University College London (GB)
- Uganda Virus Research Institute (UG)
Publication Details
- Journal
- Trials
- Published
- 2025-11-10
- DOI
- https://doi.org/10.1186/s13063-025-09138-5
- Primary Topic
- HIV/AIDS Research and Interventions
- Type
- article
- Field-Weighted Citation Impact
- 0.00