Unilateral palpebral and bilateral orbital xanthogranuloma: An unusual presentation of adult-onset xanthogranuloma responding to tocilizumab

This case illustrates a rare anatomical presentation of AOX with unilateral eyelid involvement and bilateral orbital extension. It underscores the importance of thorough systemic evaluation, long-term follow-up to monitor for progression to other AOXGD subtypes such as AAPOX, and the potential role of biologic agents like tocilizumab in achieving disease control while reducing corticosteroid exposure.

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Publication Details

Journal
American Journal of Ophthalmology Case Reports
Published
2025-11-11
DOI
https://doi.org/10.1016/j.ajoc.2025.102469
Primary Topic
Histiocytic Disorders and Treatments
Type
article
Field-Weighted Citation Impact
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article

Unilateral palpebral and bilateral orbital xanthogranuloma: An unusual presentation of adult-onset xanthogranuloma responding to tocilizumab

Sara Isabel Plazola-Hernández, J. G. Palacios Vargas, Abelardo Rodríguez-Reyes, Karla Itatí Llerenas-Aguirre et al.
American Journal of Ophthalmology Case Reports
Histiocytic Disorders and Treatments
article

Unilateral palpebral and bilateral orbital xanthogranuloma: An unusual presentation of adult-onset xanthogranuloma responding to tocilizumab

Sara Isabel Plazola-Hernández, J. G. Palacios Vargas, Abelardo Rodríguez-Reyes, Karla Itatí Llerenas-Aguirre, O. Delgado, Zair Omar Salgado Mancilla
article en

Abstract

This case illustrates a rare anatomical presentation of AOX with unilateral eyelid involvement and bilateral orbital extension. It underscores the importance of thorough systemic evaluation, long-term follow-up to monitor for progression to other AOXGD subtypes such as AAPOX, and the potential role of biologic agents like tocilizumab in achieving disease control while reducing corticosteroid exposure.

American Journal of Ophthalmology Case ReportsVol. 40
Asociacion Para Evitar la Ceguera en México Hospital Dr. Luis Sánchez Bulnes (MX), Institute for Social Security and Services for State Workers (MX), Universidad Nacional Autónoma de México (MX)
Openalex Percentile: Top 59%
Histiocytic Disorders and Treatments
DOIOpen Access PDFOpenAlex
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