Time-Dependent Effect of Anti-seizure Medications on Bone Metabolism in Patients with Epilepsy: A Cross-Sectional Study
PWE exhibit dynamic bone metabolic alterations. Following > 2 years of ASM therapy, osteoclast inhibition precedes the onset of osteoblast dysfunction. Prolonged ASM exposure eventually reduces bone formation markers, indicating progressive impairment of osteoblastic function and a concomitant decline in bone-forming capacity. Consequently, the β-CTX/OC ratio represents a pivotal early biomarker for monitoring bone health deterioration, demonstrating significant clinical utility.
Authors
- Xiuying Chen (ORCID: https://orcid.org/0009-0006-1851-583X)
- Bofei Chen
- Huali Luo (ORCID: https://orcid.org/0000-0001-5966-3683)
- Yi Shi (ORCID: https://orcid.org/0000-0003-3005-9655)
- Zhu Qiu (ORCID: https://orcid.org/0009-0004-1320-2151)
- Lina Jiang (ORCID: https://orcid.org/0000-0003-0404-1179)
- Lei Chen (ORCID: https://orcid.org/0000-0001-5263-5540)
- Jiahui Guo (ORCID: https://orcid.org/0009-0006-1522-0120)
- Yi-Xiang Wang (ORCID: https://orcid.org/0000-0002-4021-4228)
- Jiajia Fang
- Beibei Shen
- Ping Su (ORCID: https://orcid.org/0000-0002-5187-4889)
Institutions
- Zhejiang International Studies University (CN)
- Zhejiang Chinese Medical University (CN)
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Neurology and Therapy
- Published
- 2025-11-11
- DOI
- https://doi.org/10.1007/s40120-025-00853-4
- Primary Topic
- Pharmacological Effects and Toxicity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Science and Technology Program of Zhejiang Province