Prognostic value of body composition on early recurrence and long-term survival of resectable pancreatic ductal adenocarcinoma
Question What are the associations of CT-evaluated body composition with early recurrence and overall survival in patients with pancreatic ductal adenocarcinoma after resection? Findings High visceral-to-subcutaneous fat ratio is an independent predictor for early recurrence, whereas high skeletal muscle density and subcutaneous fat area independently predict better overall survival. Clinical relevance Combining body composition and clinicopathological indicators (carbohydrate antigen 19-9, carbohydrate antigen 12-5, tumor-node-metastasis stage, lymphovascular invasion, and adjuvant therapy) enables reliable prediction of postoperative prognosis in pancreatic ductal adenocarcinoma patients.
Authors
- Tong Nie (ORCID: https://orcid.org/0009-0003-2544-3780)
- Heshui Wu
- Hongying Wu
- Chuansheng Zheng (ORCID: https://orcid.org/0000-0002-2435-1417)
- Davy Xuesong Ouyang
- Feihong Wu (ORCID: https://orcid.org/0000-0002-2476-4203)
- Linxia Wu (ORCID: https://orcid.org/0009-0003-7191-4600)
- Xin Li (ORCID: https://orcid.org/0000-0002-7647-8620)
- Lei Chen (ORCID: https://orcid.org/0000-0002-7110-892X)
- Ping Han (ORCID: https://orcid.org/0000-0003-0758-6668)
- Licai Zhang (ORCID: https://orcid.org/0000-0003-2349-6996)
- Xiaoling Zhi
Institutions
- Hubei Provincial Center for Disease Control and Prevention (CN)
- Wuhan Union Hospital (CN)
- Union Hospital (CN)
- Hubei University (CN)
Publication Details
- Journal
- European Radiology
- Published
- 2025-11-10
- DOI
- https://doi.org/10.1007/s00330-025-12028-8
- Citations
- 2
- Primary Topic
- Nutrition and Health in Aging
- Type
- article
- Field-Weighted Citation Impact
- 2.33
Funders
- National Natural Science Foundation of China
- Guangdong Provincial People's Hospital
- National Key Research and Development Program of China