A Population Pharmacokinetic and Exposure–Response Analysis for Baricitinib in Pediatric Patients with Atopic Dermatitis
The population PK model developed using baricitinib concentrations from adult patients, with allometric scaling for weight on clearance and volume, adequately predicted exposures in the pediatric population. The PK modeling, with E-R analysis, informed an appropriate weight-based dosing regimen.
Authors
- David B. Radtke (ORCID: https://orcid.org/0009-0005-5103-5013)
- Rodney L. Decker (ORCID: https://orcid.org/0000-0002-6224-6722)
- Xin Zhang (ORCID: https://orcid.org/0000-0002-4064-6805)
- Apurva Prakash
- C. Steven Ernest
Institutions
- Eli Lilly (United States) (US)
- Metrum Research Group (United States) (US)
Publication Details
- Journal
- Clinical Pharmacokinetics
- Published
- 2025-11-10
- DOI
- https://doi.org/10.1007/s40262-025-01563-8
- Primary Topic
- Dermatology and Skin Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Eli Lilly and Company