Improving the Analysis of KCCQ Endpoints in Heart Failure Clinical Trials
Conventional analyses of treatment effects on overall mean KCCQ score changes lead to misinterpretations in clinical trials, but this can be mitigated by using methods allowing for baseline-dependent effects.
Authors
- Robin Myte (ORCID: https://orcid.org/0000-0002-2974-2003)
- Martin Rensfeldt
- Yunyun Jiang (ORCID: https://orcid.org/0000-0002-4438-1613)
- John Eriksson (ORCID: https://orcid.org/0000-0001-7028-0069)
- Ayman Al‐Shurbaji
- Per Nyström
Institutions
- AstraZeneca (Brazil) (BR)
- AstraZeneca (Finland) (FI)
Publication Details
- Journal
- Therapeutic Innovation & Regulatory Science
- Published
- 2025-11-10
- DOI
- https://doi.org/10.1007/s43441-025-00888-7
- Primary Topic
- Heart Failure Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00