Cluster Analysis to Identify Distinct Asthma Phenotypes in the <scp>ATLANTIS</scp> Cohort
Four distinct clusters were identified, where the presence of SAD was associated with high type-2 inflammation, lower lung function, and frequent exacerbations. SAD may be a marker of poorly controlled asthma and should be considered as an important clinical trait.
Authors
- Maarten van den Berge (ORCID: https://orcid.org/0000-0002-9336-7340)
- Irene H. Heijink (ORCID: https://orcid.org/0000-0002-1260-8932)
- Salman Siddiqui (ORCID: https://orcid.org/0000-0003-3770-7870)
- Leonardo Michele Fabbri (ORCID: https://orcid.org/0000-0001-8894-1689)
- Simon D. Pouwels (ORCID: https://orcid.org/0000-0001-7345-8061)
- Jorine E. Hartman (ORCID: https://orcid.org/0000-0001-8765-9673)
- Klaus F. Rabe (ORCID: https://orcid.org/0000-0002-7020-1401)
- Alberto Papi (ORCID: https://orcid.org/0000-0002-6924-4500)
- Christopher Edward Brightling (ORCID: https://orcid.org/0000-0002-9345-4903)
- Dirk‐Jan Slebos (ORCID: https://orcid.org/0000-0001-9555-3422)
- M. Kraft (ORCID: https://orcid.org/0009-0000-9941-3558)
- Bianca Beghé (ORCID: https://orcid.org/0000-0003-2894-1964)
- Xingnan Li (ORCID: https://orcid.org/0000-0002-1208-8658)
- Pauline J.M. Kuks (ORCID: https://orcid.org/0009-0005-0220-8985)
- Dave Singh (ORCID: https://orcid.org/0000-0001-8918-7075)
- Janwillem W.H. Kocks (ORCID: https://orcid.org/0000-0002-2760-0693)
- Tatiana Karp (ORCID: https://orcid.org/0009-0003-6435-4545)
- Huib A. M. Kerstjens (ORCID: https://orcid.org/0000-0001-7705-7927)
- Ulrica Scaffidi‐Argentina
Institutions
- University of Modena and Reggio Emilia (IT)
- University Medical Center Groningen (NL)
- University of Leicester (GB)
- University of Groningen (NL)
- University of Ferrara (IT)
- Christian-Albrechts-Universität zu Kiel (DE)
- Manchester University NHS Foundation Trust (GB)
- General Practitioners Research Institute (NL)
- Mount Sinai Medical Center (US)
- Observational & Pragmatic Research Institute (SG)
- Chiesi Foundation (IT)
- LungenClinic Grosshansdorf (DE)
- Chiesi (Italy) (IT)
- NIHR Leicester Biomedical Research Centre (GB)
- Imperial College London (GB)
- Chiesi (France) (FR)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Allergy
- Published
- 2025-11-10
- DOI
- https://doi.org/10.1111/all.70127
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00