Comparison of Cytoplasmic and Nuclear <scp>MTAP</scp> Loss in Pleural Effusion Cytology: Correlation With Homozygous p16/ <scp>CDKN2A</scp> Deletion
Our findings demonstrate that while nuclear and cytoplasmic MTAP loss are concordant in presence, staining patterns and antibody clone selection affect correlation with p16/CDKN2A deletion. Given that pleural effusion cytology is often the initial diagnostic step in PM, standardised MTAP testing protocols are needed to ensure reproducibility and minimise false-negative interpretations, rather than implying improved diagnostic accuracy.
Authors
- Güntülü Ak (ORCID: https://orcid.org/0000-0001-8849-193X)
- Muzaffer Metintaş (ORCID: https://orcid.org/0000-0002-4812-0170)
- Selma Metintaş (ORCID: https://orcid.org/0000-0002-5002-5041)
- Emine Dündar (ORCID: https://orcid.org/0000-0001-5675-0124)
- Nazlı Sena Şeker (ORCID: https://orcid.org/0000-0003-4588-7250)
- Emel Tekin (ORCID: https://orcid.org/0000-0001-7297-9869)
- Osman Furkan Mülkem (ORCID: https://orcid.org/0000-0001-9875-1985)
Institutions
- Eskişehir Osmangazi University (TR)
Publication Details
- Journal
- Cytopathology
- Published
- 2025-11-10
- DOI
- https://doi.org/10.1111/cyt.70034
- Primary Topic
- Pleural and Pulmonary Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00