Association between Toll-like receptor 9 signaling defect and developing post-infectious irritable bowel syndrome
TLR9 deficiency leads to bradykinin receptor upregulation in the colonic epithelium following infectious colitis, contributing to the development of PI-IBS. Inhibition of these receptors alleviated visceral pain, indicating that bradykinin receptor antagonists may offer a novel therapeutic strategy for PI-IBS.
Authors
- Kenjiro Matsumoto (ORCID: https://orcid.org/0000-0003-3315-1203)
- Yoshiyuki Mishima (ORCID: https://orcid.org/0000-0001-5261-6411)
- Shunji Ishihara (ORCID: https://orcid.org/0000-0002-8228-1912)
- Haruki Usuda (ORCID: https://orcid.org/0000-0002-3664-5519)
- Kenichi Kishimoto
- Akihiko Oka (ORCID: https://orcid.org/0000-0001-6451-8413)
- Kousaku Kawashima (ORCID: https://orcid.org/0000-0002-5815-0066)
- Naoki Oshima (ORCID: https://orcid.org/0000-0002-0861-9970)
- Koichiro Wada (ORCID: https://orcid.org/0000-0001-9231-0556)
- Satoshi Kotani (ORCID: https://orcid.org/0000-0002-8916-8904)
Institutions
- Shimane University (JP)
- Shimane University Hospital (JP)
- Doshisha Women's College of Liberal Arts (JP)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-11-10
- DOI
- https://doi.org/10.3389/fimmu.2025.1672117
- Primary Topic
- Immune Response and Inflammation
- Type
- article
- Field-Weighted Citation Impact
- 0.00