Imbalanced Innervation of the Hypothalamic Paraventricular Nucleus by the AgRP and α-Melanocyte-Stimulating Hormone Axonal Projections in Germ-Free Mice
These data reveal that gut microbiota plays a modulatory role in the development of the ARC/PVN axonal projections. An imbalance between AgRP and α-MSH innervation in germ-free mice may contribute to their metabolic and behavioral alterations.
Authors
- Sergueı̈ O. Fetissov (ORCID: https://orcid.org/0000-0002-2491-4945)
- Sylvie Rabot (ORCID: https://orcid.org/0000-0002-4603-2038)
- Mouna El Mehdi
- Emilie Lahaye (ORCID: https://orcid.org/0000-0002-5785-5785)
- Aurélie Balvay (ORCID: https://orcid.org/0000-0003-1701-4241)
- Oarii Vahirua
Institutions
- Inserm (FR)
- AgroParisTech (FR)
- Université Paris-Saclay (FR)
- Microbiologie de l’alimentation au service de la santé (FR)
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
- Différenciation et Communication Neuronale et Neuroendocrine (FR)
- Université de Rouen Normandie (FR)
Publication Details
- Journal
- Developmental Neuroscience
- Published
- 2025-11-10
- DOI
- https://doi.org/10.1159/000549483
- Primary Topic
- Stress Responses and Cortisol
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission
- Agence Nationale de la Recherche
- Institut National de la Santé et de la Recherche Médicale
- Bundesministerium für Bildung und Forschung
- Horizon 2020 Framework Programme