Developing and validating a clinical prediction model to predict epilepsy-related emergency department attendance, hospital admission, or death: A cohort study protocol
This large study will develop and validate a CPM for PWE, creating an internationally generalisable tool for subsequent clinical implementation. It will predict the joint risk of acute admission and death in PWE. Mortality prediction is highlighted by NICE as a key recommendation for epilepsy research. The study has been co-developed by epilepsy researchers and members of the public affected by epilepsy.
Authors
- Anthony G Marson (ORCID: https://orcid.org/0000-0002-6861-8806)
- Iain Buchan (ORCID: https://orcid.org/0000-0003-3392-1650)
- Laura Bonnett (ORCID: https://orcid.org/0000-0002-6981-9212)
- Glen Philip Martin (ORCID: https://orcid.org/0000-0002-3410-9472)
- Gashirai K. Mbizvo (ORCID: https://orcid.org/0000-0002-9588-2944)
- Pietá Schofield (ORCID: https://orcid.org/0000-0002-6398-2537)
- Gregory Y.H. Lip (ORCID: https://orcid.org/0000-0002-7566-1626)
- William Owen Pickrell (ORCID: https://orcid.org/0000-0003-4396-5657)
- Hilary Garret
- Alan Griffiths
Institutions
- Swansea Bay University Health Board (GB)
- University of Liverpool (GB)
- Manchester Academic Health Science Centre (GB)
- Morriston Hospital (GB)
- Walton Centre (GB)
- University of Manchester (GB)
- Swansea University (GB)
- Liverpool Heart and Chest Hospital (GB)
- Liverpool John Moores University (GB)
- Aalborg University (DK)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-11-10
- DOI
- https://doi.org/10.1371/journal.pone.0328809
- Primary Topic
- Epilepsy research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute for Health and Care Research