Role of the Choroid Plexus Kir7.1 Channel in the Regulation of Mouse Cerebrospinal Fluid K <sup>+</sup> Concentration
Kir7.1 imparts high K<sup>+</sup> permeability and defines the membrane potential of CPE cells. Its unusual [K<sup>+</sup>]<sub>o</sub>-independent conductance underpins its important role in the regulation of [K<sup>+</sup>]<sub>CSF</sub>. Moreover, Kir7.1 appears crucial for NKCC1 function, likely these two proteins forming part of an apical complex with the Na<sup>+</sup>-K<sup>+</sup>-ATPase. Given the continuity of CSF with brain interstitial space, Kir7.1-mediated control of [K<sup>+</sup>]<sub>CSF</sub> might influence neuronal excitability.
Authors
- Johanna Burgos (ORCID: https://orcid.org/0009-0000-9563-2729)
- Erwin Vera (ORCID: https://orcid.org/0009-0009-6887-5237)
- Isabel Cornejo (ORCID: https://orcid.org/0000-0002-8922-3045)
- Iván Ruminot (ORCID: https://orcid.org/0000-0002-3985-384X)
- L. Pablo Cid (ORCID: https://orcid.org/0000-0003-0394-0498)
- Francisco V. Sepúlveda (ORCID: https://orcid.org/0000-0003-0022-6598)
- Juan Carlos Henao (ORCID: https://orcid.org/0009-0005-4958-2456)
Institutions
- San Sebastián University (CL)
- Centro de Estudios Científicos (CL)
Publication Details
- Journal
- Acta Physiologica
- Published
- 2025-11-10
- DOI
- https://doi.org/10.1111/apha.70129
- Citations
- 1
- Primary Topic
- Ion channel regulation and function
- Type
- article
- Field-Weighted Citation Impact
- 0.81