(E)-4-(4-((8-Bromooctyl)oxy)styryl)-N,N-diphenylaniline

Triphenylamine and phenol derivatives are two types of antimicrobial molecules with broad application prospects. Through functional modification, these compounds integrate fluorescence imaging and photodynamic antibacterial therapy, thereby achieving theranostic capabilities. They exert broad-spectrum and highly efficient antimicrobial activity via a membrane-disrupting mechanism, which consequently reduces the propensity for inducing drug resistance. In this work, triphenylamine-phenol derivatives (TPO) were designed and synthesized through three consecutive reactions: Wittig reaction, Heck reaction, and substitution reaction. Double bonds, hydroxyl groups, and brominated alkyl chains were gradually introduced to finally obtain the target product (E)-4-(4-((8-bromooctyl)oxy)styryl)-N,N-diphenylaniline (5). This study provides new insights into the development of novel and highly efficient antibacterial agents.