Developing a 3D Model Culture of an EBV+/CD30+ B-Anaplastic Large Cell Lymphoma Cell Line to Assay Brentuximab Vedotin Treatment
This simple and reproducible method of generating D430B-ALCL spheroids to evaluate their response to Brentuximab Vedotin treatment, as here described, may provide a valuable preliminary tool for the future pre-clinical screening of patients' primary lymphoma cells or the development of novel therapies for this type of pathology and related diseases.
Authors
- Marco Musso (ORCID: https://orcid.org/0000-0001-6571-7609)
- Paolo Giannoni (ORCID: https://orcid.org/0000-0002-7206-376X)
- Daniela de Totero (ORCID: https://orcid.org/0000-0002-8481-7848)
- Mauro Krampera (ORCID: https://orcid.org/0000-0002-7280-2040)
- Paola Visconti (ORCID: https://orcid.org/0000-0002-4257-290X)
- Alessandro Poggi (ORCID: https://orcid.org/0000-0002-1860-430X)
- Roberto Benelli (ORCID: https://orcid.org/0000-0002-9769-0954)
- Chiara Utzeri (ORCID: https://orcid.org/0009-0007-1114-4228)
- Gabriella Pietra (ORCID: https://orcid.org/0000-0002-7080-531X)
- Monica Marchese (ORCID: https://orcid.org/0000-0002-0250-5331)
- Giuseppina Fugazza
- Orlando Izzo (ORCID: https://orcid.org/0009-0006-1395-3611)
Institutions
- University of Verona (IT)
- Ospedale Policlinico San Martino (IT)
- University of Genoa (IT)
Publication Details
- Journal
- Antibodies
- Published
- 2025-11-10
- DOI
- https://doi.org/10.3390/antib14040098
- Primary Topic
- Lymphoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministero della Salute