Prospective assessment of health-related quality of life in early phase oncology clinical trials: PEARLER
PEARLER is the first prospective cohort study investigating change in HRQoL over time in patients undergoing EP-CTs. Reassuringly, almost three-quarters of participants who undertake EP-CTs either sustain or improve their GHS or PFS. Presence of liver metastases appears to be a negative predictive marker of HRQoL.
Authors
- Joseph Descallar (ORCID: https://orcid.org/0000-0002-6919-4865)
- Adam Cooper
- Abhijit Pal (ORCID: https://orcid.org/0000-0002-4600-6569)
- Martin Hong (ORCID: https://orcid.org/0000-0002-2327-4261)
- Weng Ng (ORCID: https://orcid.org/0000-0003-2354-1857)
- Charlotte Lemech (ORCID: https://orcid.org/0000-0002-5399-9431)
- Joe Wei (ORCID: https://orcid.org/0000-0003-1944-1079)
- Christina T. Teng (ORCID: https://orcid.org/0000-0002-3716-8611)
- Praffulla Kumar Dubey
- Wei Chong Chua
- Andrew Killen (ORCID: https://orcid.org/0000-0002-2273-3753)
- Udit Nindra (ORCID: https://orcid.org/0000-0002-2612-9502)
- Aflah Roohullah (ORCID: https://orcid.org/0000-0002-4480-2529)
- Kate Wilkinson (ORCID: https://orcid.org/0000-0001-9666-2647)
- Grace Scott (ORCID: https://orcid.org/0000-0001-7905-798X)
- J. Tang (ORCID: https://orcid.org/0009-0002-7530-9953)
- Jun Hee Hong (ORCID: https://orcid.org/0000-0002-9977-7471)
- Jeneen Attaullah
Institutions
- Camden and Campbelltown Hospitals (AU)
- University of Wollongong (AU)
- Liverpool Hospital (AU)
- Wollongong Hospital (AU)
- Prince of Wales Hospital (AU)
- St Vincent's Clinic (AU)
- Ingham Institute (AU)
- South Western Sydney Local Health District (AU)
- Western Sydney University (AU)
- Neuroscience Research Australia (AU)
Publication Details
- Journal
- JNCI Cancer Spectrum
- Published
- 2025-11-03
- DOI
- https://doi.org/10.1093/jncics/pkaf108
- Primary Topic
- Management of metastatic bone disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00