Epigenetic regulation of MMP-11 and -16 expression in human prostate cancer: the role of KDM6A
KDM6A demethylates H3K27me<sub>3</sub> at MMP-11 and -16 promoters, sustaining their enhanced expression in PCa and revealing a novel epigenetic mechanism driving metastasis-associated protease expression.
Authors
- C. Kemal Buharalıoğlu (ORCID: https://orcid.org/0000-0001-6077-1550)
- Recep İlhan
- Yağmur Çakmak (ORCID: https://orcid.org/0000-0001-5777-1066)
- Gökçe Yıldırım-Buharalıoğlu (ORCID: https://orcid.org/0000-0002-4277-0084)
Institutions
- Izmir Kâtip Çelebi University (TR)
- Ege University (TR)
Publication Details
- Journal
- Epigenomics
- Published
- 2025-11-10
- DOI
- https://doi.org/10.1080/17501911.2025.2586858
- Primary Topic
- Protease and Inhibitor Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00