Japanese society for cancer of the colon and rectum (JSCCR) guidelines 2024 for the clinical practice of hereditary colorectal cancer

Approximately 5% of all colorectal cancers have a strong genetic component and are classified as hereditary colorectal cancer (HCRC). Some of the unique features commonly seen in HCRC cases include early age of onset, synchronous/metachronous cancer occurrence, and multiple cancers in other organs. These characteristics require different management approaches, including diagnosis, treatment or surveillance, from those used in the management of sporadic colorectal cancer. Accurate diagnosis of HCRC is essential because it enables targeted surveillance and risk reduction strategies that improve patient outcomes. Recent genetic advances revealed several causative genes for polyposis and non-polyposis syndromes. The Japanese Society for Cancer of the Colon and Rectum (JSCCR) first published guidelines for the management of HCRC in 2012, with subsequent revisions every 4 years. The 2024 update to the JSCCR guidelines for HCRC was developed by meticulously reviewing evidence from systematic reviews and the consensus of the JSCCR HCRC Guidelines Committee, which includes representatives from patient advocacy groups for FAP and Lynch syndrome. These guidelines provide an up-to-date summary of HCRC, along with clinical recommendations for managing FAP and Lynch syndrome.

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Publication Details

Journal
International Journal of Clinical Oncology
Published
2025-11-10
DOI
https://doi.org/10.1007/s10147-025-02892-1
Citations
1
Primary Topic
Genetic factors in colorectal cancer
Type
article
Field-Weighted Citation Impact
1.47
Controls
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article

Japanese society for cancer of the colon and rectum (JSCCR) guidelines 2024 for the clinical practice of hereditary colorectal cancer

Shigeki Sekine, Yasuki Akiyama, Michihiro Mutoh, Yuko Kawasaki et al.
1 citations
International Journal of Clinical Oncology
Genetic factors in colorectal cancer
1.47
article

Japanese society for cancer of the colon and rectum (JSCCR) guidelines 2024 for the clinical practice of hereditary colorectal cancer

Shigeki Sekine, Yasuki Akiyama, Michihiro Mutoh, Yuko Kawasaki, Takeshi Nakajima, Yasuyuki Takamizawa, Kouji Banno, Takao Hinoi, Masayoshi Yamada, Noriko Tanabe, Yoji Takeuchi, Keigo Komine, Naohiro Tomita, Kohji Tanakaya, Yoshiko Shibata, Koichi Okamoto, Hourin Cho, Akira Sakamoto, Hisashi Hasumi, Tatsuro Yamaguchi, Michio Itabashi, Masashi Miguchi, Akinari Takao, Yoshiko Nakayama, Kunitoshi Shigeyasu, Kazuhiro Sakamoto, Kensuke Kumamoto, Takahiro Horimatsu, Hideki Shimodaira, Kentaro Sakamaki, Kenta Masuda, Akiko Chino, Keiji Hirata, Yusuke Mizuuchi, Kei Ishimaru, Takahiro Yoshioka, Yusaku Shimamoto, Kenji Fujiyoshi, Misato Takao, Hideyuki Ishida, Shinji Tanaka, Kenichi Sugihara, Toshiya Nagasaki, Fumitaka Taniguchi, Sakiko Nakamori, Yoichi Ajioka, Yasuyuki Miyakura, Satoru Doi
article en
1 citations

Abstract

Approximately 5% of all colorectal cancers have a strong genetic component and are classified as hereditary colorectal cancer (HCRC). Some of the unique features commonly seen in HCRC cases include early age of onset, synchronous/metachronous cancer occurrence, and multiple cancers in other organs. These characteristics require different management approaches, including diagnosis, treatment or surveillance, from those used in the management of sporadic colorectal cancer. Accurate diagnosis of HCRC is essential because it enables targeted surveillance and risk reduction strategies that improve patient outcomes. Recent genetic advances revealed several causative genes for polyposis and non-polyposis syndromes. The Japanese Society for Cancer of the Colon and Rectum (JSCCR) first published guidelines for the management of HCRC in 2012, with subsequent revisions every 4 years. The 2024 update to the JSCCR guidelines for HCRC was developed by meticulously reviewing evidence from systematic reviews and the consensus of the JSCCR HCRC Guidelines Committee, which includes representatives from patient advocacy groups for FAP and Lynch syndrome. These guidelines provide an up-to-date summary of HCRC, along with clinical recommendations for managing FAP and Lynch syndrome.

International Journal of Clinical OncologyVol. 31(1)
Kurume University (JP), Tokyo Institute of Technology (JP), Kyushu University (JP), Shinshu University (JP), Okayama University (JP), Gunma University (JP), University of Occupational and Environmental Health Japan (JP), Kagawa University (JP), Keio University (JP), Families USA (US), Tokyo Metropolitan Komagome Hospital (JP), Juntendo University (JP), Kyoto Prefectural University of Medicine (JP), Tokyo Institute of Psychiatry (JP), Toyonaka Municipal Hospital (JP), Tohoku University Hospital (JP), Hiroshima City Asa Citizens Hospital (JP), Japan Association for Development of Community Medicine (JP), Hiroshima Prefectural Hospital (JP), Tokyo Medical University Hospital (JP), Kobe University of Fashion and Design (JP), National Institute of Technology, Akashi College (JP), Koshigaya Municipal Hospital (JP), Saitama Cancer Center (JP), Hiroshima University Hospital (JP), Tochigi Cancer Center (JP), Iwakuni Medical Center (JP), National Cancer Center Hospital East (JP), Heisei International University (JP), Kyoto University Hospital (JP), Osaka International Cancer Institute (JP), Tokyo National Hospital (JP), Social Insurance Saitama Chuo Hospital (JP), Onomichi General Hospital (JP), Japanese Foundation For Cancer Research (JP), Ehime University (JP), Kobe University (JP), Niigata University (JP), Tohoku Medical and Pharmaceutical University (JP), Saitama Medical University (JP), Yokohama City University (JP), Tokushima University (JP)
Openalex Percentile: Top 14%
Genetic factors in colorectal cancer
1.47
DOIOpen Access PDFOpenAlex
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