Regulatory effects of Sini-San on bile acid homeostasis in the enterohepatic circulation of mice with liver fibrosis
SNS may exert anti-hepatic fibrosis effects by modulating BAs metabolism and gut-liver axis pathways, ultimately restoring BAs homeostasis. These findings provide new insights into the therapeutic mechanisms of SNS and suggest its potential as a multitargeted strategy for LF treatment.
Authors
- Luyun Chen (ORCID: https://orcid.org/0000-0002-7749-9052)
- Yong Su (ORCID: https://orcid.org/0000-0003-1964-0756)
- Rou Fang
- Chaoliang Ge (ORCID: https://orcid.org/0000-0002-0082-1146)
- En Liu (ORCID: https://orcid.org/0000-0002-2437-5910)
- Yingrui Wang (ORCID: https://orcid.org/0000-0002-4198-6836)
- Yijie Ding
- Chengfeng Huang
- Fangsi Zhu
Institutions
- Anhui Medical University (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
Publication Details
- Journal
- Chinese Medicine
- Published
- 2025-11-11
- DOI
- https://doi.org/10.1186/s13020-025-01252-5
- Primary Topic
- Liver physiology and pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- China Pharmaceutical University
- Anhui Medical University