Early [18F]FDG PET/CT Response after a Single Dose of Anti-EGFR Therapy as a Predictive Biomarker for Treatment Benefit in Patients with Advanced Colorectal Cancer
Selecting patients with left-sided RAS/BRAF wild-type mCRC resulted in a 92% clinical benefit rate from anti-EGFR mAb monotherapy. Early [18F]FDG PET/CT identified nonresponders with 100% accuracy, offering promising clinical utility when tumor mutational status is unavailable.
Authors
- Sophie L. Gerritse (ORCID: https://orcid.org/0000-0002-6287-4016)
- Rutger H.T. Koornstra (ORCID: https://orcid.org/0000-0002-5446-755X)
- Elske C. Gootjes (ORCID: https://orcid.org/0009-0000-9898-2767)
- Mariëtte Labots (ORCID: https://orcid.org/0000-0002-7095-1771)
- Ronald Boellaard (ORCID: https://orcid.org/0000-0002-0313-5686)
- Erik J. van Helden (ORCID: https://orcid.org/0009-0007-2995-0420)
- Tineke E. Buffart (ORCID: https://orcid.org/0000-0003-2464-7741)
- Elisabeth G.E. de Vries (ORCID: https://orcid.org/0000-0002-8949-7425)
- Gerben J.C. Zwezerijnen (ORCID: https://orcid.org/0000-0002-9571-9362)
- C. Willemien Menke‐van der Houven van Oordt (ORCID: https://orcid.org/0000-0002-5404-5883)
- Derk Jan de Groot (ORCID: https://orcid.org/0000-0002-8306-6835)
- Anne I.J. Arens (ORCID: https://orcid.org/0000-0001-7066-5372)
- Otto S. Hoekstra (ORCID: https://orcid.org/0000-0003-0767-2734)
- Lindsay Angus (ORCID: https://orcid.org/0000-0002-7928-1102)
- Henk M.W. Verheul (ORCID: https://orcid.org/0000-0001-5981-922X)
- Hans F. M. Pruijt (ORCID: https://orcid.org/0000-0002-2067-6791)
Institutions
- University Medical Center Groningen (NL)
- Radboud University Nijmegen (NL)
- Erasmus MC (NL)
- Amsterdam UMC Location University of Amsterdam (NL)
- Radboud University Medical Center (NL)
- Reinier de Graaf Hospital (NL)
- Amsterdam Neuroscience (NL)
- Radboud Institute for Molecular Life Sciences (NL)
- Erasmus MC Cancer Institute (NL)
- Amsterdam University Medical Centers (NL)
- Rijnstate Hospital (NL)
- Jeroen Bosch Ziekenhuis (NL)
- Vrije Universiteit Amsterdam (NL)
- University of Amsterdam (NL)
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
- Erasmus University Rotterdam (NL)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2025-11-10
- DOI
- https://doi.org/10.1158/1078-0432.ccr-25-1768
- Primary Topic
- Radiomics and Machine Learning in Medical Imaging
- Type
- article
- Field-Weighted Citation Impact
- 0.00