Comparative Evaluation of Imatinib and Nilotinib in a Streptozotocin-Induced Rat Model of Alzheimer’s Disease : Neuroprotective, Anti-inflammatory, and Cognitive Outcomes
Imatinib and Nilotinib ameliorated neuroinflammation, restored neurotrophic support, and improved cognitive deficits in a preclinical Alzheimer's disease model. These findings highlight the therapeutic potential of tyrosine kinase inhibitors, warranting further translational research in human studies.
Authors
- Oytun Erbaş (ORCID: https://orcid.org/0000-0001-5427-8428)
- Gökhan Gürkan (ORCID: https://orcid.org/0000-0003-1839-1014)
- Mümin Alper Erdoğan (ORCID: https://orcid.org/0000-0003-0048-444X)
- Beyza Akdağ
Institutions
- Izmir University (TR)
- Istanbul Bilim University (TR)
- Izmir Kâtip Çelebi University (TR)
- Kütahya Dumlupınar Üniversitesi (TR)
- Kutahya Saglik Bilimleri Universitesi
Publication Details
- Journal
- Journal of Korean Neurosurgical Society
- Published
- 2025-11-10
- DOI
- https://doi.org/10.3340/jkns.2025.0110
- Primary Topic
- Chronic Myeloid Leukemia Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00