Durability of lenacapavir in viremic heavily treatment-experienced people with HIV: real-world data from the PRESTIGIO Registry
Lenacapavir, the first-in-class capsid inhibitor, targets multiple stages of the HIV lifecycle, thereby inhibiting viral replication.1 Thanks to its new mechanism of action, lenacapavir is approved for use in people with HIV (PWH) who have limited treatment options.2,3 While its efficacy has been demonstrated in clinical trials,4–6 real-world data in PWH with extensive treatment experience remain scarce. We aimed to evaluate the durability and viro-immunological outcomes of lenacapavir-containing regimens in viremic PWH harbouring four-class drug-resistant (4DR) strains
Authors
- Davide Laurenda
- Federica Malerba (ORCID: https://orcid.org/0000-0002-9105-0630)
- Daniela Valenti (ORCID: https://orcid.org/0000-0001-7638-8724)
- Silvia Lamonica
- Maurizio Zazzi (ORCID: https://orcid.org/0000-0002-0344-6281)
- Antonio Di Biagio (ORCID: https://orcid.org/0000-0003-1436-5089)
- Camilla Muccini (ORCID: https://orcid.org/0000-0002-0900-5639)
- Riccardo Lolatto (ORCID: https://orcid.org/0000-0002-2447-6498)
- Stefania Zanussi (ORCID: https://orcid.org/0000-0003-0608-9766)
- Marcello Tavio (ORCID: https://orcid.org/0000-0002-1391-8051)
- Marcello Feasi
- Roberta Gagliardini (ORCID: https://orcid.org/0000-0002-6351-2623)
- Tiziana Formenti
- Spinello Antinori (ORCID: https://orcid.org/0000-0003-0569-9407)
- Elisa Mariabelli
- Maria Mazzitelli (ORCID: https://orcid.org/0000-0003-0263-0703)
- Massimo Puoti (ORCID: https://orcid.org/0000-0003-3278-7138)
- Valentina Da Ros (ORCID: https://orcid.org/0000-0002-0124-3288)
- Simoncini Elena
- Andrea Galli (ORCID: https://orcid.org/0000-0002-4404-430X)
- Tommaso Clemente (ORCID: https://orcid.org/0000-0001-6548-3427)
- Andrea De Vito (ORCID: https://orcid.org/0000-0002-8265-5400)
- Elisa Garlassi
- Roberto Gulminetti (ORCID: https://orcid.org/0000-0002-8456-3550)
- Tiziana Mulas (ORCID: https://orcid.org/0000-0002-8761-6267)
- Manuela Colafigli (ORCID: https://orcid.org/0000-0003-1610-6347)
- Rachele Pincino
- Loredana Sarmati (ORCID: https://orcid.org/0000-0003-1452-0333)
- Maria Teresa Demitri
- Laura Comi (ORCID: https://orcid.org/0000-0002-0848-2847)
- Marcello Trizzino (ORCID: https://orcid.org/0000-0002-8105-5139)
- Giulia Nardini (ORCID: https://orcid.org/0000-0002-0471-2035)
- Martina Bottanelli (ORCID: https://orcid.org/0000-0003-1162-3513)
- Chiara Fornabaio (ORCID: https://orcid.org/0000-0001-9176-8768)
- Maria Mercedes Santoro (ORCID: https://orcid.org/0000-0002-6228-1114)
- Mirko Compagno (ORCID: https://orcid.org/0000-0002-6372-5434)
- Diletta Laccabue (ORCID: https://orcid.org/0000-0002-8612-8042)
- Massimiliano Fabbiani (ORCID: https://orcid.org/0000-0002-1343-812X)
- Stefano Nardi (ORCID: https://orcid.org/0000-0001-6906-1766)
- Anna Maria Cattelan (ORCID: https://orcid.org/0000-0003-2869-2945)
- Elio Manzillo
- Silvia Fantino
- Alessandra Ferrari (ORCID: https://orcid.org/0000-0001-7354-9895)
- Nicolò Capra (ORCID: https://orcid.org/0000-0003-1974-2015)
- Andrea Calcagno (ORCID: https://orcid.org/0000-0003-2534-8815)
- Adriana Cervo (ORCID: https://orcid.org/0000-0002-1384-7847)
- Matteo Bassetti (ORCID: https://orcid.org/0000-0002-0145-9740)
- Benedetto Maurizio Celesia (ORCID: https://orcid.org/0000-0002-6919-1955)
- Vincenzo Olivadese
- Romina Corsini
- Flavia Balena (ORCID: https://orcid.org/0000-0002-0350-8331)
- Pierluigi Viale (ORCID: https://orcid.org/0000-0003-1264-0008)
- Antonio Sarà (ORCID: https://orcid.org/0000-0003-4551-1042)
- Daniela Francisci (ORCID: https://orcid.org/0000-0001-8752-8278)
- Davide Minisci
- Paolo Fusco (ORCID: https://orcid.org/0000-0002-3949-4293)
- Elisa Fronti
- Elisabetta Schiaroli (ORCID: https://orcid.org/0000-0002-3216-4144)
- Giuseppe Vittorio De Socio (ORCID: https://orcid.org/0000-0001-8774-4843)
- Filippo Lagi (ORCID: https://orcid.org/0000-0003-0999-6070)
- Silvia Magnani (ORCID: https://orcid.org/0000-0002-3233-5564)
- Stefano Rusconi (ORCID: https://orcid.org/0000-0002-0375-9990)
- Elisabetta Carini
- Emanuele Pontali (ORCID: https://orcid.org/0000-0002-1085-0442)
- Vincenzo Spagnuolo (ORCID: https://orcid.org/0000-0002-9656-7217)
- Antonio Cascio (ORCID: https://orcid.org/0000-0002-1992-1796)
- Federico D’Amico (ORCID: https://orcid.org/0000-0001-7825-4922)
- Carmen Giarratana
- C Abeli
- Sabrina Bagaglio (ORCID: https://orcid.org/0000-0002-3671-6022)
- Francesco Castelli (ORCID: https://orcid.org/0000-0001-9161-7804)
- Alessio Bellucci (ORCID: https://orcid.org/0000-0003-3766-1921)
- Ilaria Rancan (ORCID: https://orcid.org/0000-0001-6393-4212)
- Francesca Panza (ORCID: https://orcid.org/0000-0001-6831-4362)
- Silvia Pontiggia
- Barbara Menzaghi (ORCID: https://orcid.org/0000-0002-5073-6521)
- Marisa Fusto
- Mario Tumbarello (ORCID: https://orcid.org/0000-0002-9519-8552)
- Marta Fiscon
- Pierluigi Francesco Salvo (ORCID: https://orcid.org/0000-0001-7559-7364)
- Giulia Marchetti (ORCID: https://orcid.org/0000-0002-4498-4828)
- Guido Calleri (ORCID: https://orcid.org/0000-0002-8440-1922)
- Giordano Madeddu (ORCID: https://orcid.org/0000-0001-6099-2273)
- Layla Pagnucco
- Maddalena Farinazzo
- Roberta Gagliardini
- Francesco Bassani (ORCID: https://orcid.org/0009-0001-7002-7044)
- Antonella Gallicchio
- Liana Bevilacqua
- Annalisa Saracino (ORCID: https://orcid.org/0000-0001-9558-208X)
- Federica Carli (ORCID: https://orcid.org/0000-0002-4055-234X)
- Cristina Mussini (ORCID: https://orcid.org/0000-0002-6615-4198)
- Stefania Piconi (ORCID: https://orcid.org/0000-0001-7058-1048)
- Teresa Santantonio (ORCID: https://orcid.org/0000-0002-4342-6904)
- Sergio Lo Caputo (ORCID: https://orcid.org/0000-0002-4729-7548)
- Ornella Schioppa (ORCID: https://orcid.org/0000-0001-6143-3860)
- Riccardo Riccardi (ORCID: https://orcid.org/0000-0001-7515-6622)
- Cinzia Bassoli (ORCID: https://orcid.org/0000-0002-9530-2217)
- Bruno Cacopardo (ORCID: https://orcid.org/0000-0002-7465-0714)
- Silvia Cretella (ORCID: https://orcid.org/0009-0000-1249-1618)
- Cristina Moioli
- Simone Rossetto
- Francesco Saladini (ORCID: https://orcid.org/0000-0002-9934-377X)
- Rebecka Papaioannu Borjesson (ORCID: https://orcid.org/0009-0007-6486-2231)
- A Narducci
- Michele Salvatore Paternò Raddusa (ORCID: https://orcid.org/0009-0003-2452-4407)
- Sassi Serena
- Angelo Pan (ORCID: https://orcid.org/0000-0003-2340-4916)
- Cecilia Costa (ORCID: https://orcid.org/0000-0002-2255-1271)
- Alessandro Bartoloni (ORCID: https://orcid.org/0000-0001-9758-1523)
- Vincenzo Malagnino (ORCID: https://orcid.org/0000-0002-6561-5298)
- Paola Brambilla
- Giuseppe Gullo (ORCID: https://orcid.org/0000-0001-5325-1055)
- Maria Mercedes Santoro
- Antonella Castagna
- Girolamo Piromalli
- Stefano Bonora
- Simona Di Giambenedetto
- Carlo Torti
- Giovanni Di Perri
- Giovanni Cenderello
- Sergio Ferrara (ORCID: https://orcid.org/0000-0003-0377-9630)
- Paola Corsi
- Sabrina Blanchi
- Marta Grauso
- Giancarlo Orofino
- Alessandra Mataloni Paggi
- Anna Maria Cattelan
- Lidia Gazzola
- Fabiana Trionfo Fineo
- Golnaz Torkjazi
- Simona Mongiardi
- Valsecchi Giada
- Trevisan Sasha
Institutions
- University of Rome Tor Vergata (IT)
- University of Verona (IT)
- University of Parma (IT)
- University of Padua (IT)
- Vita-Salute San Raffaele University (IT)
- University of Perugia (IT)
- Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani (IT)
- Azienda Ospedaliera Universitaria Integrata Verona (IT)
- Torino e-district (IT)
- Ospedale di Parma (IT)
- Hospital for Tropical Diseases (VN)
Publication Details
- Journal
- Journal of Antimicrobial Chemotherapy
- Published
- 2025-11-10
- DOI
- https://doi.org/10.1093/jac/dkaf415
- Primary Topic
- HIV/AIDS drug development and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00