Characterization, expression, and mutational analysis of endosomal protein lethal giant disc (Lgd/CC2D1A) as a biomarker in patients with T-cell acute lymphoblastic leukemia

Through this analysis, we reported the presence of Lgd with an altered nucleotide sequence in T-ALL patients. We also found its elevated expression compared with healthy controls, which might affect disease progression. Our investigation results also lay the foundation for the possible development of Lgd as a predictive indication for the early identification of T-ALL.