Decoding tumor heterogeneity with imaging biomarkers predicts response to TACE plus immunotherapy and targeted therapy in HCC (CHANCE2204)

An imaging radiomic biomarker that captures both global and intratumoral heterogeneity robustly predicts response and survival in patients with HCC treated with TACE-ICI-MTT, and reflects underlying immune microenvironment phenotypes.

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Publication Details

Journal
Hepatology
Published
2025-11-10
DOI
https://doi.org/10.1097/hep.0000000000001593
Citations
4
Primary Topic
Cancer Immunotherapy and Biomarkers
Type
article
Field-Weighted Citation Impact
4.18
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article

Decoding tumor heterogeneity with imaging biomarkers predicts response to TACE plus immunotherapy and targeted therapy in HCC (CHANCE2204)

Jian-Jia Chen, Rong Ding, Yang Weizhu, Chunwang Yuan et al.
4 citations
Hepatology
Cancer Immunotherapy and Biomarkers
4.18
article

Decoding tumor heterogeneity with imaging biomarkers predicts response to TACE plus immunotherapy and targeted therapy in HCC (CHANCE2204)

Jian-Jia Chen, Rong Ding, Yang Weizhu, Chunwang Yuan, Zhenwei Peng, Guohui Xu, Dongrui Li, Ruibao Liu, Anfeng Si, Chuansheng Zheng, Jianbing Wu, Guan‐Hui Zhou, Jiaping Li, Bin‐Yan Zhong, Shu-Wei Wen, Hong-Tao Hu, Yu-Qing Wang, Mingsheng Huang, Jingwei Wei, Zhicheng Jin, Yu‐Dong Xiao, Weihua Zhang, Li Chen, Jie Tian, Weidong Wang, Wei Ding, Xinying Wang, Yeming Wu, Aibing Xu, Gao‐Jun Teng, Xiaoli Zhu, Hai‐Bin Shi, Shanzhi Gu, Yangyang Xie, Haifeng Zhou, Jinze Li, Duo Wang, Haidong Zhu, Guowen Yin, Fang Nie, Jiansong Ji
article en
4 citations

Abstract

An imaging radiomic biomarker that captures both global and intratumoral heterogeneity robustly predicts response and survival in patients with HCC treated with TACE-ICI-MTT, and reflects underlying immune microenvironment phenotypes.

Hepatology
Hebei Medical University (CN), Fujian Medical University (CN), Union Hospital (HK), Central South University (CN), Nanchang University (CN), Xidian University (CN), Harbin Medical University (CN), Sun Yat-sen University (CN), Capital Medical University (CN), Chinese Academy of Sciences (CN), Kunming Medical University (CN), Nanjing General Hospital of Nanjing Military Command (CN), Sir Run Run Shaw Hospital (CN), Lishui University (CN), Nanjing University of Science and Technology (CN), Zhengzhou University (CN), Soochow University (CN), Shandong Institute of Automation (CN), Zhejiang Cancer Hospital (CN), Second Hospital of Hebei Medical University (CN), Shanxi Provincial Cancer Hospital (CN), Nantong Tumor Hospital (CN), Zhongda Hospital Southeast University (CN), Second Affiliated Hospital of Nanchang University (CN), Institute of Automation (CN), Sichuan Cancer Hospital (CN), Jiangsu Cancer Hospital (CN), The First Affiliated Hospital, Sun Yat-sen University (CN), Sun Yat-sen University Cancer Center (CN), Third Affiliated Hospital of Sun Yat-sen University (CN), Beijing YouAn Hospital (CN), Jiangsu Province Hospital (CN), First Affiliated Hospital of Soochow University (CN), Second Xiangya Hospital of Central South University (CN), Wuxi People's Hospital (CN), Union Hospital (CN), Hangzhou Cancer Hospital (CN), First Affiliated Hospital Zhejiang University (CN), Huazhong University of Science and Technology (CN), Zhejiang University (CN), Beihang University (CN), Nanjing Medical University (CN), Nanjing University (CN)
Openalex Percentile: Top 5%
Cancer Immunotherapy and Biomarkers
4.18
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