The impact of dose and discontinuation timing of preoperative ACE inhibitors on survival outcomes in cardiac surgery: A MIMIC-IV database analysis
Continuing preoperative ACEI use on the day of surgery was associated with significantly reduced postoperative mortality. Medium-dose lisinopril was associated with the most consistent reduction in postoperative mortality, although patients with malignancy may require individualized assessment. These findings suggest that evidence-based perioperative ACEI management may be beneficial and warrant further investigation.
Authors
- Xuemei Wu (ORCID: https://orcid.org/0009-0003-0895-9849)
- Xiu Zou
- Li Hu (ORCID: https://orcid.org/0000-0002-7535-6453)
- Hongqiang Qiu (ORCID: https://orcid.org/0000-0003-3285-8768)
- Jianxing Zhou (ORCID: https://orcid.org/0000-0003-4405-0440)
- Shengyang Chen (ORCID: https://orcid.org/0000-0003-1506-0615)
- Lan Sha
Institutions
- Fujian Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- First Affiliated Hospital of Fujian Medical University (CN)
- Fu Wai Hospital (CN)
- Union Hospital (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-11-10
- DOI
- https://doi.org/10.1371/journal.pone.0334889
- Primary Topic
- Cardiac, Anesthesia and Surgical Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00