Mechanical Loading Alleviates <scp>BRONJ</scp> ‐Like Lesions Around Implants Under Osteoporotic Conditions: An In Vivo Experimental Model
This study is the first to demonstrate that implant loading alleviates BRONJ stage 0-like lesions by enhancing peri-implant bone quality. Mechanical loading promotes peri-implant bone health through cellular adaptation and extracellular matrix remodeling, even under BP-treated osteoporotic-like conditions.
Authors
- Yusuke Uto
- Takashi Sawase (ORCID: https://orcid.org/0000-0002-4703-7164)
- Kazunori Nakajima (ORCID: https://orcid.org/0000-0003-1864-9425)
- Juo Pei Lee (ORCID: https://orcid.org/0009-0005-9226-5050)
- Shinichiro Kuroshima (ORCID: https://orcid.org/0000-0001-9891-9987)
Institutions
- Nagasaki Institute of Applied Science (JP)
- Hokkaido University (JP)
- Nagasaki University (JP)
Publication Details
- Journal
- Clinical Oral Implants Research
- Published
- 2025-11-10
- DOI
- https://doi.org/10.1111/clr.70064
- Citations
- 1
- Primary Topic
- Dental Implant Techniques and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 1.79