Cp*Co(III)-Catalyzed Defluorinative Allylation via Ketone-Directed C–H Activation
The first Cp*Co(III)-catalyzed <i>ortho</i>-C-H perfluoroallylation of aromatic ketones via weakly coordinating ketone-directed C-H activation was developed. This method features good functional group tolerance, high efficiency, and broad substrate scope. A variety of aromatic ketones such as propiophenones, diaryl ketones, and bioactive chalcones were compatible with this catalytic system. Furthermore, mechanistic studies reveal that the C-H activation step may not be involved in the turnover-limiting step.
Authors
- Rui Huang (ORCID: https://orcid.org/0000-0001-5952-2936)
- Yanqi Li (ORCID: https://orcid.org/0000-0002-1437-9301)
- Heyun Sheng (ORCID: https://orcid.org/0009-0005-4614-9745)
- Jiajia Yu (ORCID: https://orcid.org/0000-0002-2677-1933)
- Yongqi Yu (ORCID: https://orcid.org/0000-0001-6086-7851)
- Ting Li (ORCID: https://orcid.org/0000-0002-2186-6992)
- Wenguang Li (ORCID: https://orcid.org/0009-0003-4969-4621)
- Mengdan You
Institutions
- Anyang Academy of Agricultural Sciences (CN)
- Nanyang Normal University (CN)
- Nanyang Institute of Technology (CN)
- Pharmaceutical Biotechnology (Czechia) (CZ)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-11-10
- DOI
- https://doi.org/10.1021/acs.joc.5c02346
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00