Zalunfiban at First Medical Contact for ST-Elevation Myocardial Infarction
In patients with STEMI, zalunfiban administered at first medical contact significantly improved preintervention infarct-related patency and reduced the likelihood of a worse 30-day multicomponent hierarchical clinical end point. Zalunfiban was not associated with increased severe or life-threatening bleeding but was associated with increased mild to moderate bleeding. (Funded by CeleCor Therapeutics; CELEBRATE ClinicalTrials.gov number, NCT04825743.).
Authors
- Tim P. van de Hoef (ORCID: https://orcid.org/0000-0003-0682-0619)
- G Montalescot
- Ellis F. Unger
- Robert C. Welsh (ORCID: https://orcid.org/0000-0003-2613-9142)
- J. Wouter Jukema (ORCID: https://orcid.org/0000-0002-3246-8359)
- Karin Arkenbout (ORCID: https://orcid.org/0009-0004-0109-2792)
- Henri van de Wetering
- Fatih Arslan (ORCID: https://orcid.org/0000-0001-6598-8599)
- Patrick Ecollan
- Dragoş Vinereanu (ORCID: https://orcid.org/0000-0002-9054-8779)
- Michael Magro (ORCID: https://orcid.org/0000-0002-0581-3532)
- Rudolf T Tolsma (ORCID: https://orcid.org/0000-0001-5255-8645)
- Rick van der Vliet (ORCID: https://orcid.org/0000-0003-0764-5293)
- Janet Wittes (ORCID: https://orcid.org/0000-0002-6625-835X)
- Renicus S. Hermanides (ORCID: https://orcid.org/0000-0003-3931-2565)
- Gert K. van Houwelingen
- René Boomars
- Daniel Cociorva
- Marcel E. Durieux (ORCID: https://orcid.org/0000-0003-1479-7666)
- Barry S. Coller (ORCID: https://orcid.org/0000-0002-9078-7155)
- Lex A. W. Ruiters
- Robert P. Giugliano (ORCID: https://orcid.org/0000-0003-4110-7675)
- M. Gosselink (ORCID: https://orcid.org/0000-0002-6396-3977)
- Frédéric Lapostolle (ORCID: https://orcid.org/0000-0002-6624-6658)
- Valentin Chioncel (ORCID: https://orcid.org/0000-0003-0630-8033)
- Petr Kala (ORCID: https://orcid.org/0000-0002-4416-9065)
- Ron Pisters (ORCID: https://orcid.org/0000-0001-8965-0664)
- Saman Rasoul (ORCID: https://orcid.org/0000-0001-9662-6136)
- Jawed Polad
- Janne Beelen (ORCID: https://orcid.org/0000-0003-0804-4481)
- Ashley Verburg (ORCID: https://orcid.org/0009-0003-1995-6221)
- Wouter Remkes
- Jindra Vainer
- Béla Péter Merkely (ORCID: https://orcid.org/0000-0001-6514-0723)
- Miles Levy
- Arnoud W.J. van ‘t Hof (ORCID: https://orcid.org/0000-0002-2344-7564)
- G. Hengstman
- Alexandra Arias‐Mendoza (ORCID: https://orcid.org/0000-0002-5942-4102)
- S. A. O. F. Rikken
- J. M. ten Berg
- A van Beurden
- C. B. Granger
- James L. Januzzi (ORCID: https://orcid.org/0000-0002-8338-1798)
- N. Baron
- C. Michael Gibson
- Ben J L Van den Branden
Institutions
- Semmelweis University (HU)
- Brigham and Women's Hospital (US)
- AARP (US)
- Harvard University (US)
- University of Alberta (CA)
- Carol Davila University of Medicine and Pharmacy (RO)
- Duke University (US)
- Masaryk University (CZ)
- Leiden University Medical Center (NL)
- Medisch Spectrum Twente (NL)
- Alaska Native Medical Center (US)
- University Medical Center Utrecht (NL)
- Maastricht University (NL)
- Sorbonne Université (FR)
- Massachusetts General Hospital (US)
- Ambulance Care (Sweden) (SE)
- University Hospital Brno (CZ)
- St. Antonius Ziekenhuis (NL)
- Netherlands Heart Institute (NL)
- Amphia Ziekenhuis (NL)
- Canadian VIGOUR Centre (CA)
- Baim Institute for Clinical Research (US)
- VieCuri Medisch Centrum (NL)
- Pitié-Salpêtrière Hospital (FR)
- RED Consulting (Norway) (NO)
- Hôpital Avicenne (FR)
- Zuyderland Medisch Centrum (NL)
- Isala (NL)
- Tergooi (NL)
- Elisabeth-TweeSteden Ziekenhuis (NL)
- Rijnstate Hospital (NL)
- GGZ Oost Brabant (NL)
- Instituto Nacional de Cardiología (MX)
- Thrombolysis in Myocardial Infarction Study Group (US)
- Jeroen Bosch Ziekenhuis (NL)
- Rockefeller University (US)
Publication Details
- Journal
- NEJM Evidence
- Published
- 2025-11-10
- DOI
- https://doi.org/10.1056/evidoa2500268
- Citations
- 7
- Primary Topic
- Acute Myocardial Infarction Research
- Type
- article
- Field-Weighted Citation Impact
- 9.72