Association Between the Use of DPP4 Inhibitors and Metformin and the Risk of Cancer in Patients with Type 2 Diabetes: A Multicenter Retrospective Cohort Study Using the OMOP CDM Database
In this large multicenter study, using DPP4is and metformin showed a substantial association with a lower risk of cancer in T2DM patients relative to other GLDs. These findings suggest a potential protective effect of metformin and support the neutral-to-beneficial effect on cancer of DPP4is.
Authors
- Gyu Lee Kim (ORCID: https://orcid.org/0000-0003-2825-0629)
- Sang Yeoup Lee (ORCID: https://orcid.org/0000-0002-3585-9910)
- Eun Ju Park (ORCID: https://orcid.org/0000-0003-2415-8243)
- Yu Hyeon Yi (ORCID: https://orcid.org/0000-0002-1786-2737)
- Ryuk Jun Kwon (ORCID: https://orcid.org/0000-0001-7757-7412)
- Young Ju Jin (ORCID: https://orcid.org/0000-0001-7428-5123)
- Young Jin Tak (ORCID: https://orcid.org/0000-0002-4645-5866)
- Jung In Choi (ORCID: https://orcid.org/0000-0003-3832-3393)
- Young Hye Cho (ORCID: https://orcid.org/0000-0003-2176-6227)
- Soo Min Son (ORCID: https://orcid.org/0000-0002-0165-7480)
- Byung Kwan Choi (ORCID: https://orcid.org/0000-0001-5244-4592)
- Jeong Gyu Lee (ORCID: https://orcid.org/0000-0001-7160-0714)
- Seung Hun Lee (ORCID: https://orcid.org/0000-0001-9041-3156)
- Youngin Lee (ORCID: https://orcid.org/0000-0003-0141-7484)
- Sae Rom Lee (ORCID: https://orcid.org/0000-0003-3736-3393)
Institutions
- Pusan National University Hospital (KR)
- Pusan National University Yangsan Hospital (KR)
- Pusan National University (KR)
Publication Details
- Journal
- Cancers
- Published
- 2025-11-10
- DOI
- https://doi.org/10.3390/cancers17223620
- Primary Topic
- Metabolism, Diabetes, and Cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00