Enhanced antimycobacterial efficacy of simulated inhaled clofazimine versus oral clofazimine in combination with azithromycin and ethambutol in a hollow-fiber system
Inhalation of clofazimine with an azithromycin-ethambutol backbone increases treatment efficacy and decreases the development of macrolide resistance compared to oral administration in a hollow-fiber system. This calls for a clinical trial of inhaled clofazimine.
Authors
- Jakko van Ingen (ORCID: https://orcid.org/0000-0002-0581-2003)
- J. A. M. Raaijmakers (ORCID: https://orcid.org/0000-0001-7250-5647)
- Ralf Stemkens (ORCID: https://orcid.org/0009-0008-6912-4163)
- Wouter Hoefsloot (ORCID: https://orcid.org/0000-0003-1007-1075)
- Heiman Wertheim (ORCID: https://orcid.org/0000-0002-5003-5565)
- Lindsey te Brake
- Rob E. Aarnoutse (ORCID: https://orcid.org/0000-0001-8925-969X)
Institutions
- Radboud University Nijmegen (NL)
- Radboud University Medical Center (NL)
- Radboud Institute for Molecular Life Sciences (NL)
Publication Details
- Journal
- Journal of Antimicrobial Chemotherapy
- Published
- 2025-11-10
- DOI
- https://doi.org/10.1093/jac/dkaf402
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Radboud Universitair Medisch Centrum