S-shaped association between hs-CRP/HDL-C index and overweight/obesity in children and adolescents: a population-based study

This study finds that the hs-CRP/HDL-C index is associated with overweight and obesity in children and adolescents in a manner that is not linear. There is a critical range (0.653-1.593) where higher values of the index are related to lower rates of overweight and obesity. Based on these results, it is recommended that pediatric healthcare providers use hs-CRP/HDL-C testing routinely, which may help identify children at risk and support early obesity prevention. Future studies should confirm these findings in additional groups and develop more effective interventions.