Epigenetic regulation of NR5A2 influences colorectal cancer cell stemness via a stemness-related transcription factor NANOG
This study identifies NR5A2 as a novel, actionable therapeutic target in CRC. Pharmacological modulation of NR5A2 disrupts CSC-driven stemness, potentially preventing relapse and improving treatment outcomes. These findings provide a strong rationale for the development of NR5A2-targeted therapies, either as monotherapy or in combination with chemotherapy, to optimize CRC patient care.
Authors
- Jiefu Wang (ORCID: https://orcid.org/0000-0001-6164-342X)
- Zhan Yang (ORCID: https://orcid.org/0000-0001-7191-2910)
- Jia Liu (ORCID: https://orcid.org/0000-0002-4528-5199)
- Liang Zhang (ORCID: https://orcid.org/0000-0002-5041-8005)
- Wenpeng Wang (ORCID: https://orcid.org/0000-0002-1151-7203)
- Li Li (ORCID: https://orcid.org/0009-0003-4636-9487)
- Dalu Kong (ORCID: https://orcid.org/0000-0003-4595-8426)
- Lei Zheng (ORCID: https://orcid.org/0000-0002-8342-5236)
Institutions
- Tianjin Medical University Cancer Institute and Hospital (CN)
- Jiuquan Iron & Steel (China) (CN)
- Tianjin Infectious Diseases Hospital (CN)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-11-10
- DOI
- https://doi.org/10.1186/s12964-025-02477-5
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Tianjin Medical University