Detection of extracellular amyloid beta aggregates by an Aducanumab-based synNotch receptor: an in vitro proof-of-concept study
These findings establish that synNotch receptors can be engineered to detect and respond to pathological extracellular protein aggregates such as Aβ. This expands the scope of synNotch-based systems and supports their potential for developing precision cell-based therapies for neurodegenerative diseases like AD.
Authors
- Cynthia J. Siebrand (ORCID: https://orcid.org/0000-0001-5422-1835)
- Suckwon Lee
- Julie K. Andersen (ORCID: https://orcid.org/0000-0003-1324-4875)
- Chaska C. Walton (ORCID: https://orcid.org/0000-0001-8513-0207)
- Nicholas J. Bergo
- Zachary Mayeri
Institutions
- University of Southern California (US)
- Buck Institute for Research on Aging (US)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-11-10
- DOI
- https://doi.org/10.1186/s12967-025-07324-2
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health