Peroxynitrite regulates ER stress-mediated Ca2+ flux to mitochondria characterizing cardiac microvascular ischemia–reperfusion injury associated with hyperhomocysteinemia
Altogether, our results reveal the pathological role of Hcy in acute cardiovascular events. We show that HHcy aggravates cardiac microvascular I/R injury via ONOO<sup>-</sup>-driven ER stress that triggers IP3R-mediated Ca<sup>2+</sup> mis-handling, culminating in mitochondrial dysfunction and necroptosis. These data identify IP3R-dependent Ca<sup>2+</sup> transfer as a tractable pathway for HHcy-complicated reperfusion injury.
Authors
- Xinyu Tan (ORCID: https://orcid.org/0000-0001-6849-0606)
- Shansong Gao
- Wan Zhang (ORCID: https://orcid.org/0000-0001-5980-8862)
- Ning Wang (ORCID: https://orcid.org/0000-0002-1849-1747)
- Haipeng Liu (ORCID: https://orcid.org/0000-0002-8045-6416)
- Xiaoming Liu (ORCID: https://orcid.org/0000-0002-1811-8758)
- Siyang Yu (ORCID: https://orcid.org/0000-0002-4007-0383)
- Qian He (ORCID: https://orcid.org/0000-0002-8230-0941)
- Kaiyang Zhao
- Chengpeng Qiu
Institutions
- Nanchang University (CN)
- China-Japan Friendship Hospital (CN)
- First Affiliated Hospital of Jiangxi Medical College (CN)
- Third Affiliated Hospital of Nanchang University (CN)
- Jiangxi Chest Hospital (CN)
- First Affiliated Hospital of Nanchang University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-11-10
- DOI
- https://doi.org/10.1186/s12967-025-07263-y
- Citations
- 2
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 1.61