Cuproptosis-driven astrocyte reactivity exacerbates experimental cerebral malaria pathogenesis
These findings establish that cuproptosis exacerbates ECM pathogenesis by promoting astrocyte reactivity, highlighting copper homeostasis modulation as a potential therapeutic strategy for CM.
Authors
- Zhifeng Deng (ORCID: https://orcid.org/0000-0003-3529-0549)
- Jiamei Gao (ORCID: https://orcid.org/0009-0009-8131-213X)
- Xinpeng Hou
- Bo Huang (ORCID: https://orcid.org/0000-0001-6196-5373)
- Xiaobao Jin (ORCID: https://orcid.org/0000-0001-5450-1730)
- Hui Yin (ORCID: https://orcid.org/0000-0002-1590-4075)
- Chien‐Tsai Lai
- Xiumei Mo (ORCID: https://orcid.org/0000-0001-9238-6171)
- Xiaoran Zhang (ORCID: https://orcid.org/0000-0001-6421-0355)
- Tao Liu (ORCID: https://orcid.org/0000-0002-7710-7557)
- Qi Wang (ORCID: https://orcid.org/0000-0002-3246-0971)
- M Ye
- Xiaoyan Chen (ORCID: https://orcid.org/0000-0002-0036-8257)
- Lirong Wu
- Zhenlong Liu (ORCID: https://orcid.org/0000-0001-9149-7179)
- Wenbin Liu (ORCID: https://orcid.org/0000-0001-9091-3177)
- Jie Wang (ORCID: https://orcid.org/0000-0002-9555-5476)
- Jianping Song (ORCID: https://orcid.org/0000-0002-5429-0440)
- Jia He (ORCID: https://orcid.org/0009-0002-4766-6718)
- Xingda Zeng
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Guangdong Pharmaceutical University (CN)
- Guangzhou University (CN)
- Guangzhou Experimental Station (CN)
- First People's Hospital of Foshan (CN)
- Foshan Second People's Hospital (CN)
- Guangzhou Chest Hospital (CN)
- McGill University (CA)
Publication Details
- Journal
- Parasites & Vectors
- Published
- 2025-11-10
- DOI
- https://doi.org/10.1186/s13071-025-07107-0
- Primary Topic
- Trace Elements in Health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Traditional Chinese Medicine Bureau of Guangdong Province
- Division of Graduate Education